Call For Paper Volume: V, Issue: 08 | AUGUST 2026 | International Journal of Advanced Trends in Engineering and Management (IJATEM)
Volume V | Issue 5 | 2026 | Paper ID: IJATEM-V05I05P5

Explainable Heart Failure Outcome Prediction Using TabPFN and Cuckoo Search Optimization for Intelligent Healthcare Prognostic Analytics

, Pradheep T Rajan B

Heart Failure (HF) is a serious cardiovascular disease, and challenges in accurate prediction, model optimization and clinical interpretability limit effective decision making. To overcome these issues, this paper proposes a Cuckoo Search Optimization (CSO) optimized TabPFN model (CSO-TabPFN) for reliable and explainable heart failure prediction. The input data set is pre-processed to handle the missing and invalid values and then visualization is done to find important relationships and patterns among the features. Feature scaling and normalization are performed before the dataset is split into training and testing subsets. TabPFN allows fast prediction from tabular clinical data. CSO optimizes the model parameters for improved prediction accuracy and robustness. The proposed model achieved an accuracy, precision, recall and F1-score of 97% and an AUC of 0.9973. SHAP analysis indicates that slope, chest pain and resting blood pressure are important predictive features, increasing model transparency and clinical interpretability.

HF, CSO, TabPFN, ML, SHAP Analysis.

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